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Regulatory bodies, including the FDA and EMA, require comprehensive immunogenicity testing during clinical development, including method validation, sample handling, and data traceability

The study found a higher risk of NAION in patients prescribed GLP-1 compared to those on non-GLP-1 RA medications

Evidence from rodent studies indicates that TB500 can impact gene networks controlling cellular migration, extracellular matrix turnover, and inflammatory response regulators, contributing to transcriptional profiles that favor remodeling rather than persistent inflammation (28,29)

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