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Upon reaching the hypoxic tumor region, the azo bond cleavage triggered Au-BSA-L-WZB117 disassembly, leading to burst release of WZB117 to inhibit GLUT1 transport activity

Clinical trials stop after a few years, and some of the currently FDA-approved drugs have only been around for a couple of years

Moreover, the transcription factor c-Jun, encoded by the proto-oncogene JUN , upregulates GLS through coordinated transcriptional and post-translational mechanisms

It is important to point out that all groups of patients remarkably improved their oxidative stress condition