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The Role of Glucagon-Like Peptide-1 Agonists in the Treatment of Multiple Sclerosis: A Narrative Review

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A meta-analysis also reported that the initial combination of a SGLT2 inhibitor with metformin led to superior reductions in HbA1c and body weight compared to monotherapy with either agent [482]

This combined systemic, direct hepatic, anti-addictive, and even anti-viral action establishes GLP-1RAs as a powerful, novel approach to reduce the cumulative toxic insults driving SLD progression across multiple etiologies