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In rare cases, more serious side effects can occur, such as allergic reactions or anaphylaxis

Some of these discrepancies between reported ASP and MUC are so significant, that if we were to accept the ASPs as submitted and base payment for these diagnostic radiopharmaceuticals off the reported ASP, the result would be more than one diagnostic radiopharmaceutical accounting for billions of dollars in projected payment in CY 2026 and these diagnostic radiopharmaceuticals would be estimated to be among the top 10 highest paid HCPCS codes in all of the OPPS

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That's a rule payers enforce through NCCI edits

DOI Jansen T, Romiti R, Kreuter A, Altmeyer P