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Immune-mediated mechanisms - production of autoantibodies to thyroid antigens and lymphocytic thyroid infiltration - are involved in the pathogenesis of AITD
Core transcriptomic programmes, encoding key LC functions such as protein targeting to ER (BH adj p = 5.67E82), ubiquitin proteinase ligase binding (BH adj p = 5.83E10), and antigen processing and presentation (BH adj p = 7.38E9), key for LC function 33 , were up-regulated in LCs isolated from control patch test sites of HDM-reactive vs
GSH is manufactured in the cytosol by a two-step process: the first step, which combines cysteine and glutamate, is catalyzed by -glutamylcysteine synthetase (GCS)
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