Informed consent was obtained from all individual participants involved in the study

Characteristics of normal urinary changes during Saxenda treatment include: Gradual increase in frequency over the first few weeks Clear or pale yellow urine indicating good hydration No pain, burning, or discomfort during urination Reasonable sleep patterns (though some nocturia is normal, especially in older adults) Correlation with increased water intake or dietary changes Conversely, concerning symptoms that warrant medical evaluation include: Excessive thirst (polydipsia) accompanied by very frequent urination (polyuria)potentially indicating hyperglycaemia or diabetes (consider checking blood glucose and urine ketones if available) Painful urination (dysuria), urgency, or sensation of incomplete bladder emptyingsuggesting urinary tract infection Blood in the urine (haematuria), even if microscopic or intermittent Nocturia (waking multiple times nightly to urinate) that significantly disrupts sleep Urinary incontinence or sudden inability to control bladder function Dark, concentrated urine despite adequate fluid intakepossibly indicating dehydration Fever with flank pain or rigorssuggesting possible kidney infection (pyelonephritis) Patients should also monitor for signs of dehydration , which can occur if increased urination is not matched by adequate fluid replacement

A trial published in the New England Journal of Medicine revealed that retatrutide helped patients achieve significant body weight loss
Two years after discontinuation of semaglutide (timepoint 3), 2 subjects reported occasional liquid stools, 2 experienced occasional nausea and dyspepsia and 1 had occasional bloating
Editorial selection Why glutathione supplementation is complicated For years, the conventional view in the research community was that oral glutathione supplementation was a waste of money