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7 As the first approved dual agonist targeting both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, tirzepatide demonstrated weight loss exceeding 20% in its pivotal trials, establishing a new therapeutic ceiling

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In preclinical studies, Ipamorelin has demonstrated minimal effects on cortisol, prolactin, and aldosterone levels at GH-stimulating concentrations, making it a cleaner research tool for isolating GH-specific effects

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