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Maintaining the redox balance Oxidative stress is defined by an imbalance between oxidants and antioxidants, which arises from the excessive generation of ROS and a decrease in the rate of their elimination by the antioxidant defense system

The chart converts common research amounts into syringe units and milliliter volumes

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ROS homeostasis and metabolism: a dangerous liaison in cancer cells

As such, many putative target genes of NRF2 still require full validation, including chromatin immunoprecipitation (ChIP)-based identification of NRF2-ARE binding and mutation of putative AREs to ensure functionality as well as determination of their (patho)physiological relevance