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Lai X transfected Prohibitin 2 (PHB2) siRNA lentiviral particles into SH-SYSY cells treated with matrix metalloproteinase (MPP) (+) and found that Rut had a protective effect in PHB2 cells, but was inhibited in PHB2 silenced cells, suggesting that Rut may play its neuroprotective role by reducing oxidative damage and the depolarization level of mitochondrial membrane potential through PHB2 mediated mitochondrial autophagy ( in vivo (Zamani et al