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Nrf2-dependent antioxidant pathway Allicin was also found to upregulate the expression of glutamate-cysteine ligase (GCL), the rate-limiting enzyme in glutathione synthesis, and other Phase II detoxifying/antioxidant enzymes, likely via the activation of the nuclear factor E2-related factor 2 (Nrf2)-dependent pathway (19)

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Conclusions There may be a greater level of risk associated with pharmaceutical trials but as our experience has highlighted non-pharmaceutical trials are not, as is sometimes assumed, risk free

Front Public Health 12 , 1456640 (2024)

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