Amino Acids 42:22232232 Mailloux RJ, Seifert EL, Bouillaud F, Aguer C, Collins S, Harper ME (2011) Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3
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EM density map and the model are shown for GLP-1, PF 06882961, OWL-833 and all seven TM helices, and ECLs of the GLP-1R when bound to each agonist
The impact of defective GLP1R cell surface expression suggests that pharmacological chaperons, molecules known to facilitate proper export of proteins to the cell surface, might be of therapeutic relevance for mutation carriers, as already shown for other important metabolic receptors such as melanocortin MC4 receptor