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For others, semaglutide offers a nonsurgical approach that, when guided by clinicians and anchored in nutrition and behavior change, may lead to significant weight loss

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The combination may therefore produce additive effects on cardiovascular parameters, making this combination potentially unsuitable for individuals with: Uncontrolled hypertension History of cardiovascular disease Arrhythmias or significant heart rhythm disorders Hyperthyroidism Hypoglycaemia risk should be considered, particularly in patients taking Rybelsus for diabetes management alongside other glucose-lowering medications

Furthermore, pathway analysis of patient groups revealed four transcriptome groups