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Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes

O'Brien ML, Tew KD

On the other hand, a more recent study from 2015 found that beta-arbutin is more effective both on mouse melanoma cells and on human melanoma cells (btw, kojic acid was the most effective on human melanoma cells)

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However, in order to do so, it must have as its starting material Linoleic Acid, this is an essential fatty acid that our body is unable to make and we must ingest it as part of our everyday diets.