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These antioxidants decreased ROS production and abolished neuroinflammation in OXA-treated mice without affecting antitumor activity nor hematological toxicity of OXA in vivo ( Some manganese (Mn)-based MRI contrast agents, such as mangafodipir and calmangafodipir, possess a mimic mitochondrial enzyme manganese superoxide dismutase (MnSOD) activity and, thus, could be utilized as a cytoprotector in PIPN

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